Ei-HDL-kolesteroli on mitta kaikista kolesterolityypeistä, jotka voivat edistää valtimoiden plakkien kertymistä, mukaan lukien LDL (matalatiheyksinen lipoproteiini), VLDL (erittäin matalatiheyksinen lipoproteiini) ja muut aterogeeniset lipidipartikkelit. Se lasketaan vähentämällä HDL (korkeatiheyksinen lipoproteiini) eli ”hyvä” kolesteroli kokonaiskolesterolista. Non-HDL-kolesteroli katsotaan kattavammaksi sydän- ja verisuonitautien riskin indikaattoriksi kuin pelkkä LDL-kolesteroli, koska se heijastaa kaikkia haitallisia kolesterolihiukkasia.
Testing for non-HDL cholesterol is beneficial for individuals at risk for cardiovascular diseases, similar to those who should monitor their LDL levels. This includes adults over 20 as part of regular health check-ups, those with a family history of high cholesterol or heart disease, individuals with a lifestyle that includes smoking, a high-fat diet, or minimal physical activity, and patients with conditions like diabetes or hypertension. It’s also important for individuals who have been identified with high total or LDL cholesterol levels.
There are usually no direct symptoms indicating high non-HDL cholesterol levels. It tends to be asymptomatic like other forms of cholesterol imbalance. High levels are typically detected through blood tests during health screenings.
Improving non-HDL cholesterol involves similar strategies to lowering LDL cholesterol. This includes adopting a heart-healthy diet low in saturated and trans fats, increasing physical activity, maintaining a healthy weight, quitting smoking, and limiting alcohol intake. In cases where lifestyle changes aren’t enough, medications like statins might be prescribed to help lower these cholesterol levels, particularly in individuals at high risk for cardiovascular diseases.
The factors affecting non-HDL cholesterol are similar to those impacting overall cholesterol levels. Diet, particularly the intake of saturated and trans fats, plays a significant role. Genetics can influence how your body processes and manages cholesterol. Lack of physical activity, obesity, and smoking are key lifestyle factors that negatively impact non-HDL cholesterol levels. Age and gender also influence these levels, with risks generally increasing with age. Certain health conditions, such as diabetes and hypothyroidism, and some medications can also affect non-HDL cholesterol levels.